Location: New York,NY, USA
Position: Scientist
Location: 430 E 29th St, New York, NY 10016
Employment: Full-time
Reports to: Chief Scientific Officer
Background
With a rapidly growing team of immunologists and genome engineers and backed by top-tier TechBio investors, OverT Bio is developing effective and safe cellular therapies for solid tumors. Founded in 2022 by Drs. Mat Legut and Neville Sanjana, OverT Bio has pioneered new pooled functional screening and synthetic genomics platforms (OverTarget and OverTCR ) to develop next-generation engineered immune cells. The science behind these platforms has been published in leading journals including Nature, The New England Journal of Medicine, and Nature Reviews Cancer.
Position Summary
This position offers the opportunity to work in a multidisciplinary team on cutting-edge technologies at the intersection of genome engineering, immuno-oncology and single-cell multiomics. In particular, you will focus on research areas such as T cell engineering, in vitro and in vivo characterization, and development of a research-scale manufacturing process. The successful candidate will be an excellent team player and a diligent experimental biologist who can thrive in a fast-paced startup environment.
Key Responsibilities
o Design, execute and analyze complex experiments across both in vitro and in vivo systems for characterization of engineered T cells in the context of solid tumor cancers,
o Develop new assays, models and processes for efficient and robust engineering of specific T cell subsets,
o Utilize cutting-edge high throughput and multi-omic technologies to gain better understanding of the productive anti-tumor response in clinically-relevant settings,
o Become the subject matter expert able to find creative solutions to unexpected problems.
Requirements
o PhD in Immunology or equivalent,
o Minimum of 2 years of cell therapy experience in industry,
o Experience with primary human T cell engineering is essential,
o Experience with gamma delta T cells or TCR-transduced T cells is preferred,
o Demonstrated proficiency with flow cytometry, co-culture assays, cytotoxicity and other immune related assays,
o Willingness to quickly discover and learn new methods and approaches,
o Ability to adjust rapidly to shifting priorities and deliver high-quality, detail-oriented results in a timely manner,
o Teamwork and collaborative attitude are essential,
o Strong organizational and record-keeping skills,
o Authorized to work in the US.
Compensation and Benefits
As one of the initial employees of an early-stage, high-growth biotech startup, you will have an excellent opportunity for personal growth at the company expands and your ideas will be critical for developing the company culture and policies. Team members will also have many opportunities to advance their knowledge and expertise through fundamental tumor immunology and synthetic biology research in a well-funded environment. We offer a generous compensation and benefit package to all employees:
o Competitive compensation commensurate with experience, typically in the $100,000-130,000 base salary range;
o Employee stock options;
o Medical, dental and vision (100% premium covered by the employer);
o 401(k) with 100% match on first 5% of employee contributions;
o 15 days vacation, with one day added after every year of service;
o 10 paid federal and other major holidays.
Please reach out with your resume to ...@overt.bio and reference this job description.